Cardinals vs. Chargers Week 1 Predictions, Odds and Stats

Los Angeles Rams v Los Angeles Chargers

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In the matchup between the Los Angeles Chargers and Arizona Cardinals on Sunday, Sept. 13 at 4:25 p.m. ET, our projection system expects the Chargers to come away with the victory. Seeking predictions on the final score, spread, and point total, too? Find a complete game projection below.

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Cardinals vs. Chargers Game Info and TV Channel

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Listen to the game on ALT 98.7

Cardinals vs. Chargers Odds and Betting Info

  • Spread favorite: Chargers (-9.5)
  • Moneyline: Chargers (-510), Cardinals (+384)
  • Total: 47.5 points

Cardinals vs. Chargers Prediction

  • Pick ATS: Chargers (-9.5)
  • Pick OU: Under (47.5)

Prediction:

Chargers 28 - Cardinals 17

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Cardinals vs. Chargers Betting Insights (2025 Stats)

    • The Chargers went 9-8-0 ATS last season.
    • The Cardinals won six games against the spread last season, while failing to cover 11 times.
    • Los Angeles covered the spread once when favored by 9.5 points or more last season (in two opportunities).
    • Arizona was an underdog by 9.5 points or more four times last season, and covered the spread in one of those games.
    • Last season, seven of the Chargers' games hit the over.
    • Cardinals games hit the over 10 out of 17 times last year.

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